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  <title>amoxi❖tabs<sup>®</sup>
    <br/>(amoxicillin tablets), USP<br/>
    <br/>Veterinary Tablets<br/>
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              <content styleCode="italics">For use in dogs and cats</content>
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          <title>CAUTION</title>
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            <paragraph>Federal law restricts this drug to use by or on the order of a licensed veterinarian</paragraph>
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          <title>DESCRIPTION</title>
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            <paragraph>Amoxi-Tabs (amoxicillin tablets) is a semisynthetic antibiotic with a broad spectrum of activity. It provides bactericidal activity against a wide range of common gram-positive and gram-negative pathogens. Chemically, it is D(-)-a-amino-p-hydroxybenzyl penicillin trihydrate.</paragraph>
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            <paragraph>Amoxi-Tabs is stable in the presence of gastric acid and may be given without regard to meals. It is rapidly absorbed after oral administration. It diffuses readily into most body tissues and fluids with the exception of brain and  spinal fluid, except when meninges are inflamed. Most of the amoxicillin is excreted unchanged in the urine.</paragraph>
            <paragraph>Amoxicillin is similar to ampicillin in its bactericidal action against susceptible organisms. It acts through the inhibition of biosynthesis of cell wall mucopeptide. <content styleCode="italics">In vitro </content>and/or <content styleCode="italics">in vivo </content>studies have demonstrated the susceptibility of most strains of the following gram-positive and gram-negative bacteria: a- and b-haemolytic streptococci, nonpenicillinase-producing staphylococci, <content styleCode="italics">Streptococcus faecalis</content>, <content styleCode="italics">Escherichia coli</content>, and <content styleCode="italics">Proteus mirabilis</content>. Because it does not resist destruction by penicillinase, it is not effective against penicillinase-producing bacteria, particularly resistant staphylococci. All strains of <content styleCode="italics">Pseudomonas </content>and most strains of <content styleCode="italics">Klebsiella </content>and <content styleCode="italics">Enterobacter </content>are resistant</paragraph>
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          <title>INDICATIONS AND USAGE</title>
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            <paragraph>
              <content styleCode="italics">
                <content styleCode="bold">Dogs:</content>
              </content>Amoxi-Tabs are indicated in the treatment of susceptible strains of the organisms causing the following infections:</paragraph>
            <paragraph>Respiratory tract infections (tonsillitis, tracheobronchitis) due to <content styleCode="italics">Staphylococcus aureus</content>, <content styleCode="italics">Streptococcus </content>spp<content styleCode="italics">.</content>, <content styleCode="italics">E. coli</content>, and <content styleCode="italics">Proteus mirabilis.</content>
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            <paragraph>Genitourinary tract infections (cystitis) due to <content styleCode="italics">Staphylococcus aureus</content>, <content styleCode="italics">Streptococcus </content>spp<content styleCode="italics">., </content>
              <content styleCode="italics">E. coli, </content>and <content styleCode="italics">Proteus mirabilis. </content>
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            <paragraph>Gastrointestinal tract infections (bacterial gastroenteritis) due to <content styleCode="italics">Staphylococcus aureus</content>, <content styleCode="italics">Streptococcus </content>spp<content styleCode="italics">.</content>, <content styleCode="italics">E. coli</content>, and <content styleCode="italics">Proteus mirabilis</content>. </paragraph>
            <paragraph>Bacterial dermatitis due to <content styleCode="italics">Staphylococcus aureus</content>, <content styleCode="italics">Streptococcus </content>spp<content styleCode="italics">.</content>, and <content styleCode="italics">Proteus mirabilis</content>. </paragraph>
            <paragraph>Soft tissue infections (abscesses, lacerations,and wounds) due to <content styleCode="italics">Staphylococcus aureus</content>, <content styleCode="italics">Streptococcus </content>spp<content styleCode="italics">.</content>, <content styleCode="italics">E. coli</content>, and <content styleCode="italics">Proteus mirabilis</content>.</paragraph>
            <paragraph>
              <content styleCode="italics">
                <content styleCode="bold"> </content>
              </content>
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              <content styleCode="italics">
                <content styleCode="bold">Cats:</content>
              </content>Amoxi-Tabs are indicated in the treatment of susceptible strains of the organisms causing the following infections: </paragraph>
            <paragraph>Upper respiratory tract infections due to <content styleCode="italics">Staphylococcus aureus</content>, <content styleCode="italics">Streptococcus </content>spp<content styleCode="italics">.</content>, and <content styleCode="italics">E. coli. </content>
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            <paragraph>Genitourinary tract infections (cystitis) due to <content styleCode="italics">Staphylococcus aureus</content>, <content styleCode="italics">Streptococcus </content>spp<content styleCode="italics">.</content>, <content styleCode="italics">E. coli</content>, and <content styleCode="italics">Proteus mirabilis. </content>
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            <paragraph>Gastrointestinal tract infections due to <content styleCode="italics">E. coli. </content>
            </paragraph>
            <paragraph>Skin and soft tissue infections (abscesses, lacerations, and wounds) due to <content styleCode="italics">Staphylococcus </content>
              <content styleCode="italics">aureus, Streptococcus </content>spp., <content styleCode="italics">E. coli</content>, and <content styleCode="italics">Pasteurella </content>
              <content styleCode="italics">multocida</content>.</paragraph>
            <paragraph>As with all antibiotics, appropriate <content styleCode="italics">in vitro </content>culturing and susceptibility testing of samples taken before treatment should be conducted.</paragraph>
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              <content styleCode="bold"> </content>The use of this drug is contraindicated in animals with a history of an allergic reaction to penicillin.</paragraph>
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            <paragraph>For use in dogs and cats only</paragraph>
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              <content styleCode="bold"> </content>Amoxicillin is a semisynthetic penicillin and has the potential for producing allergic reactions. If an allergic reaction occurs, administer epinephrine and/or steroids</paragraph>
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              <content styleCode="italics">Dogs: </content>The recommended dosage is 5 mg/lb of body weight twice a day.</paragraph>
            <paragraph>
              <content styleCode="italics">Cats: </content>The recommended dosage is 50 mg (5–10 mg/lb) once a day.</paragraph>
            <paragraph>Dosage should be continued for 5–7 days or 48 hours after all symptoms have subsided. If no improvement is seen in 5 days, review diagnosis and change therapy.</paragraph>
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              <content styleCode="bold">Do Not Store at Temperatures Above 25°C (77°F)</content>
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            <paragraph>
              <content styleCode="bold">Keep Bottle Tightly Closed.</content>
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              <content styleCode="bold"> </content>Amoxi-Tabs are supplied in 5 strengths: 50 mg, 100 mg, 150 mg, and 200 mg in bottles of 500 tablets; 400 mg in bottles of 250 tablets.</paragraph>
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            <paragraph>Approved by FDA under NADA # 055-078<br/>Approved by FDA under NADA # 055-081<br/>
              <br/>
              <content styleCode="bold">zoetis</content>
              <br/>
              <br/>Distributed by:<br/>Zoetis Inc.<br/>Kalamazoo, MI 49007<br/>
              <br/>P1523357<br/>Revised: January 2020</paragraph>
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