|
|
Week 2 Week 3 Week 4 Week 5 Week 6 |
100 mg 150 mg 200 mg 300 mg 400 mg |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Adverse Reaction |
|
|||
---|---|---|---|---|
|
|
|||
|
||||
|
|
|
|
|
|
|
|
|
|
|
||||
|
|
|
|
|
|
|
|
||
|
|
|
||
|
||||
|
|
|
|
|
|
|
|
||
|
|
|
||
|
|
|
||
|
|
|
||
|
|
|
||
|
|
|
||
|
||||
|
|
|
||
|
|
|
||
|
|
|
||
|
|
|
||
|
||||
|
|
|
||
|
||||
|
|
|
|
|
|
||||
|
|
|
||
|
||||
|
|
|
||
|
|
|
||
|
|
|
|
|
|
|
|
||
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
||
|
|
|
||
|
|
|
|
|
|
|
|
||
|
|
|
||
|
|
|
||
|
||||
|
|
|
||
|
||||
|
|
|
||
|
|
|
||
|
||||
|
|
|
|
|
|
|
|
|
|
|
||||
|
|
|
|
|
|
|
|
||
|
|
|
|
|
|
|
|
||
|
||||
|
|
|
|
|
|
|
|
||
|
|
|
|
|
|
|
|
||
|
||||
|
|
|
||
|
||||
|
|
|
||
|
|
|
|
|
|
|
|
||
|
|
|
||
|
||||
|
|
|
Adverse Reaction |
|
|
---|---|---|
|
|
|
|
||
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
||
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
||
|
|
|
|
|
|
|
|
|
|
|
|
|
||
|
|
|
|
||
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
||
|
|
|
|
||
|
|
|
|
|
|
|
|
|
|
||
|
|
|
|
|
|
Adverse Reaction |
|
|
---|---|---|
|
||
|
|
|
|
|
|
|
||
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
||
|
|
|
|
|
|
|
|
|
|
|
|
|
||
|
|
|
|
||
|
|
|
|
|
|
|
||
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
||
|
|
|
|
||
|
|
|
|
||
|
|
|
|
||
|
|
|
|
|||
---|---|---|---|
Adverse Reaction |
|
|
|
|
|||
|
|
|
|
|
|
|
|
|
|||
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|||
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|||
|
|
|
|
|
|||
|
|
|
|
|
|||
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|||
|
|
|
|
|
|||
|
|
|
|
|
|||
|
|
|
|
|
|||
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|||
|
|
|
|
|
|||
|
|
|
|
|
|||
|
|
|
|
|
|||
|
|
|
|
Adverse Reaction |
|
|
|
---|---|---|---|
|
|
||
|
|||
|
|
|
|
|
|
|
|
|
|||
|
|
|
|
|
|
|
|
|
|||
|
|
|
|
|
|
|
|
|
|||
|
|
|
|
|
|||
|
|
|
|
|
|
|
|
|
|
|
|
|
|||
|
|
|
|
|
|||
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|||
|
|
|
|
|
|||
|
|
|
|
Adverse Reaction |
|
|
---|---|---|
|
||
|
|
|
|
|
|
|
|
|
|
||
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
||
|
|
|
|
||
|
|
|
|
||
|
|
|
|
|
|
|
|
|
|
|
---|---|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
---|---|---|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
||||
|
|
|
|
|
|||
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|||||
---|---|---|---|---|---|---|---|---|
|
|
|
|
|
|
|||
|
||||||||
|
Median % Reduction % Responders |
12 18 |
27a 24 |
48ᵇ 44ᵈ |
45ᶜ 46ᵈ |
|
|
|
|
Median % Reduction % Responders |
2 9 |
|
|
41ᶜ 40ᶜ |
41ᶜ 41ᶜ |
36ᶜ 36ᵈ |
|
|
Median % Reduction % Responders |
1 8 |
|
41e 35ᵈ |
|
|
|
|
|
Median% Reduction % Responders |
-12 10 |
|
|
46ᶠ 47ᶜ |
|
|
|
|
Median % Reduction % Responders |
-21 0 |
|
|
|
24ᶜ 43ᶜ |
|
|
|
Median % Reduction % Responders |
20 24 |
44ᶜ 45ᶜ |
|
|
|
|
|
|
||||||||
|
Median % Reduction % Responders |
11 20 |
|
|
|
|
|
33ᵈ 39 |
|
||||||||
|
Median % Reduction % Responders |
9 20 |
|
|
|
|
|
57ᵈ 56ᶜ |
|
||||||||
|
Median % Reduction % Responders Improvement in Seizure Severityᶨ |
-5 14 |
|
|
|
|
|
15ᵈ 28ᵍ |
|
|
|
|
|
|
|
|
|
|
|
|||
|
|
|
|
|
|||
|
|
|
|
|
|||
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|